How a scientist-artist transformed our view of the brain

The Brain in Search of ItselfBenjamin EhrlichFarrar, Straus and Giroux, $35Spani

The Brain in Search of Itself
Benjamin Ehrlich
Farrar, Straus and Giroux, $35

Spanish anatomist Santiago Ramón y Cajal is known as the father of modern neuroscience. Cajal was the first to see that the brain is built of discrete cells, the “butterflies of the soul,” as he put it, that hold our memories, thoughts and emotions.

With the same unflinching scrutiny that Cajal applied to cells, biographer Benjamin Ehrlich examines Cajal’s life. In The Brain in Search of Itself, Ehrlich sketches Cajal as he moved through his life, capturing moments both mundane and extraordinary.

Some of the portraits show Cajal as a young boy in the mid-19th century. He was born in the mountains of Spain. As a child, he yearned to be an artist despite his disapproving and domineering father. Other portraits show him as a barber-surgeon’s apprentice, a deeply insecure bodybuilder, a writer of romance stories, a photographer and a military physician suffering from malaria in Cuba.

The book is meticulously researched and utterly comprehensive, covering the time before Cajal’s birth to after his death in 1934 at age 82. Ehrlich pulls out significant moments that bring readers inside Cajal’s mind through his own writings in journals and books. These glimpses help situate Cajal’s scientific discoveries within the broader context of his life.

Through his detailed drawings, Santiago Ramón y Cajal revealed a new view of the brain and its cells, such as these two Purkinje cells that Cajal observed in a pigeon’s cerebellum.Science History Images/Alamy Stock Photo

Cajal and Golgi’s irreconcilable ideas — and their hostility toward each other — came through clearly from speeches they gave after their prizes were awarded. “Whoever believed in the ‘so-called’ independence of nerve cells, [Golgi] sneered, had not observed the evidence closely enough,” Ehrlich writes. The next day, Cajal countered with a precise, forceful rebuttal, detailing his work on “nearly all the organs of the nervous system and on a large number of zoological species.” He added, “I have never [encountered] a single observed fact contrary to these assertions.”

Cajal’s fiercely defended insights came from careful observations, and his intuitive drawings of nerve cells did much to convince others that he was right (SN: 2/27/21, p. 32). But as the book makes clear, Cajal was not a mere automaton who copied exactly the object in front of him. Like any artist, he saw through the extraneous details of his subjects and captured their essence. “He did not copy images — he created them,” Ehrlich writes. Cajal’s insights “bear the unique stamp of his mind and his experience of the world in which he lived.”

This biography draws a vivid picture of that world.


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