Controlled Release Society (CRS)_Education & Science

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CRS members are creating the future of delivery science and technology through fundamental delivery research, development, regulatory science, and clinical translation. Research published in CRS journals and presented during the Annual Meeting & Exposition offers a breadth of scientific knowledge covering new technologies and science in the multi-disciplinary delivery field.Learn More Equity, Diversity & Inclusion Featured Videos "Bioresponsive Drug Delivery"Learn More Featured Events CRS 2022 Annual MeetingJuly 11 - 15, 2022Montreal, Canada New This Month CRS 2022 Board Election Results Announced! View hereCRS 2022 Award Winners Announced!Click to see the winners CRS 2022 Annual Meeting Click to view the 2022 Annual Meeting Video REGISTRATION OPEN Drug Delivery and Translational Research (DDTR) What's New?Role of drug delivery technologies in the success of COVID-19 vaccines: a perspectiveThis newly published DDTR “Perspective” article discusses the roles of drug delivery technologies in developing safe and efficacious vaccines. We thank Drs. Robert Langer, Pieter Cullis, Olivia Merkel and Mark Prausnitz for sharing their perspectives and insights on this important topic.June 2022 Issue of DDTRBest Paper of the June 2022 Issue of DDTR: Summary: The goal of the current research was to develop an ImM (tyrosine kinase inhibitor) containing nanoformulation and to determine if kidney delivery could be improved over traditional ImM in order to potentially treat nephritis secondary to systemic lupus erythematosus (SLEN). The glomerulus is the location within the kidney targeted in SLEN. A fish oil–based ImM oil-in-water nanoemulsion was developed and characterized for particle size, zeta potential, pH, and stability. MRL/MpJ-Faslpr (a mouse model of SLEN) and control mice (MRL-MpJ) were employed. The nanoemulsion characteristics were favorable for renal deposition (60-80 nm size, zeta potential of −6.6 to −7.8 mV, polydispersity index < 0.3, 3-day stability at 4 °C) and demonstrated limited leakage. Kidney deposition of ImM was found to be threefold higher in mice that received the nanoformulation versus naked formulation. Future strategies will define dose-efficacy and dose-toxicity relationships, and characterize and evaluate approaches to further enhance kidney deposition.Melanie Joy talks about DDTR, an official journal of the CRS. Inspirational NoteInspirational note by James Goodson and Dr. Paul RotaInnovations in vaccine delivery: increasing access, coverage, and equity and lessons learnt from measles and rubella eliminationIn this inspirational note, James Goodson and Dr. Paul Rota provide insightful and timely perspective and discussion regarding the importance of vaccine delivery technology and multidisciplinary efforts to achieve global vaccination and ultimately well-being.Inspirational note by Dr. Andrew L. LewisDevelopment and approval of rybelsus (oral semaglutide): ushering in a new era in peptide deliveryIn this Inspirational Note, Dr. Andrew Lewis and coauthors feature an amazing and innovative discovery that is changing the paradigm of oral peptide delivery. Inspirational note by Drs. Lara Milane and Mansoor AmijiClinical approval of nanotechnology-based SARS-CoV-2 mRNA vaccines: impact on translational nanomedicineIn this Inspirational Note, Drs. Lara Milane and Mansoor Amiji share their insights and reflections on the impact of the recently approved SARS-CoV-2 mRNA vaccines on the present and future of translational nanomedicines.Inspirational note by Alexander (Sandy) T. Florence Trajectories in nanotechnology: embracing complexity, seeking analogies"A timely and truly insightful Inspirational Note by one of the fathers of nanotechnology & pharmaceuticals.” -Jung Soo Suk, Ph.D., Assistant Professor, The Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of MedicineInspirational Note from Dr. Marianne Ashford, Senior Principal Scientist in Glocal Advanced Drug Delivery Group in Pharmaceutical Sciences at AstraZeneca "Drug delivery - the increasing momentum" "In this 'Inspirational Note' you will be inspired by the way industry sees advances in drug delivery and Nanomedicine. Dr. Marianne Ashford talks about the 'increasing momentum'. You should not miss this note if you are interested in translational research." -Prof. Maria José Alonso, Editor-in-Chief of the Drug Delivery and Translational Research (DDTR) Journal, Past President of the Controlled Release SocietyInspirational Note from Dr. Robert Langer"From micro to nano: evolution and impact of drug delivery in treating disease"In this Inspirational Note, Robert Langer and Jeff Hrkach highlight the technological evolution of drug delivery from micro to nano, providing examples of clinically approved medicines that demonstrate the significant impact of the drug delivery field on treating many diseases.2020 DDTR Best Paper of the Year: Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B.2019 DDTR Best Paper of the Year: Depletion of collagen by losartan to improve tumor accumulation and therapeutic efficacy of photodynamic nanoplatformsThe Best Paper is chosen by the DDTR Editorial Board.2019 CRS Nanomedicine and Nanoscale Delivery (NND) Best Paper of the Year: Tumor growth inhibition by mSTEAP peptide nanovaccine inducing augmented CD8+ T cell immune responses2019 DDTR CRS Oral Drug Delivery Focus Group Paper of the Year Award: Loratadine self-microemulsifying drug delivery systems (SMEDDS) in combination with sulforaphane for the synergistic chemoprevention of pancreatic cancerDDTR VideosEditor-in-Chief ArticleDrug Delivery and Translational Research is a journal published by CRS, providing a unique forum for the scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. The journal is published 6 times a year and will be available online to CRS members as part of their annual dues.Drug Delivery and Translational Research EditorsDrug Delivery and Translational Research Editorial Board Women In Science Visit the WIS PageUpdate from Women in Science Chair, Maria Jose Alonso Annual Meeting Women In Science Keynote Women in ScienceThe CRS WIS ran two very successful sessions during the virtual CRS2020 Annual Meeting. Prof. Alonso delivered a very inspirational talk about her career in science that prompted a lively Q&A session where participants could ask their questions live, triggering a collegial and warm atmosphere. We are super proud to announce that this year we had over 150 participants of different nationalities and seniorities, of which a fair amount were men, which we warmly welcome. This allowed a virtual mingling with women CRS past presidents, past Women in Science Award Winners, and peers.Thank you all for making these sessions an outstanding success and especially thanks to Prof. Alonso for willingly sharing her legacy in science and her path to get there. We are looking forward to welcoming your ideas and experiences and to keep us all engaged. Please contact Ruth Schmid with any questions. We also hope to see you face-to-face in Montreal in 2021! Professionally managed by Association Headquarters, a charter accredited association management company. Copyright © 2022 Controlled Release Society. All Rights Reserved.