NANOPROBES: Gold nanoparticles and Nanogold for immunolabeling, EM, LM, fluorescence microscopy, and micro-CT x-ray contrast agents._Home & Family

Celebrating 25 years of innovation! Tel: 631-205-9490 Fax: 631-205-9493 US toll free: 877-447-6266 647 FluoroNanogold� for Super-Res! How to order from us You can now order from Thermo Fisher Scientific International Distributors Product Catalog Index[ View All Products ][ search ]AuroVist™ 15 nm & 1.9 nmX-ray Contrast Agent Unparalleled for microCT - Highest contrast, longest half-lifeNanogold® (1.4 nm gold) ConjugatesAntibody Conjugates Fab' or IgGFluoroNanogold™Fluorescence and gold labeling with one probe.Check your labeling by fluorescence before EM prep.647 for Super-Res!Lipid Conjugates1.4 nm Nanogold® or 0.8 nm UndecagoldStreptavidin ConjugatesEnhancement / Developers GoldEnhance™Silver EnhancementEnzMet™ Staining and DetectionEnzymatic deposition of silver: Superfine stainingUltrasensitive detectionGold Nanomaterials:Coated Nanoparticles 3 nm and 5 nm Choose: hydrophilic, amphiphilic, or hydrophobicGold Nanoparticle Labeling ReagentsLabel your own antibodies and probes Choice of reactive groups for conjugationPositive, negative or uncharged1.4 nm Nanogold®0.8 nm UndecagoldHistadine (His) Tag Labeling Recombinant Protein Detection GoldiBlot™ for Westerns Ni-NTA-Nanogold®10 nm, 5 nm & 1.8 nm FerroMag™ Magnetic nanoparticlesSuperparamagnetic and biocompatibleNegative Stains for EM NanoVan™ (vanadium)Nano-W™ (organotungsten)Xray Contrast AgentsAuroVist™15 nm & 1.9 nm Unparalleled for microCT - Highest contrast, longest half-lifeEnzMet™ ultra-sensitiveEnzymatic deposition of silverfor superfine detection Current Price List (pdf) Custom Synthesis Instructions and MSDS Nanoprobes Gold Nanoparticles: Nanogold® Labels for Imaging & MicroscopyUpdated: February 21, 2022UpdatesCOVID-19: Following New York Forward guidelines, Nanoprobes is now operating on a regular schedule, and we are now open during our regular business hours (Monday through Friday, 8:30 AM - 5:00 PM Eastern Time). We remain committed to keeping our team, products and operations safe and disease-free, and will continue to follow guidance from the Centers for Disease Control, World Health Organization and New York State Department of Health. We are currently unable to ship directly to Japan. If you wish to order products for shipment to Japan, please contact one of our International Distributors for Japan. New Products: 5 nm Click Nanogold® and 1.4 nm DBCO-Nanogold®Choose: copper-free or copper-catalyzed Click labeling! Now available: our 5 nm Click Nanogold® reagents are the first 5 nm Nanogold® labeling reagents. Available with azido-, alkyne, and DBCO functionality for copper-catalyzed (CuAAC) and copper-free (SPAAC) click labeling. Bioorthogonal labeling lets you label selectively in living cells, tissues and even animals without cross-reactivity. Label dynamic processes then pick your time to fix and observe their parts at the macromolecular level. Stable, biocompatible and well tolerated by living cells: do not disrupt life processes or cell viability. Undecagold (0.8 nm) available for specialized high-resolution EM applications. Featured Application: Western BlottingDetect His-tagged or native proteins quickly and easily with high sensitivity GoldiBlot™ detects His-tagged recombinant proteins. Binding strength comparable to antibodies, fast development and consistent performance. No antibodies required: procedure complete in 1 hour 15 minutes. Learn more EnzMet™ provides super-sensitive detection of native, unmodified proteins: just replace DAB or other organic chromogens in almost any peroxidase-based procedure. Learn more The Power ofFluoroNanogold™comes to Super-Resolution! 2-in-1 Labels for BOTH Super-Res and TEM See your target in its cellular context! Alexa Fluor® 647 dye for Super-Res (STORM) PLUS Nanogold® particles for visibility in TEM Covalently bound for stability, long working times Convenient secondary antibody/Fab' or streptavidin Get both in a single, standard labeling procedure Easy kits to enhance for light/phase microscopy AuroVist™ is our unique gold nanoparticle X-ray contrast agent! Unparalleled for Micro CT AuroVist™-15 nm: Highest contrast of any blood pool contrast agent Longest blood half-life of any x-ray contrast agent -24 hrs! AuroVist™ 1.9 nm: Highest kidney contrast available In vivo MicroCT after AuroVist™ 15 nm injectionNote very high contrast in blood and heart, with little accumulation in the liver. Mouse images from our Nanoparticle Research Collaborative. Not yet approved for clinical use. Very well tolerated-- Great for in vivo vascular imaging. 5nm Ni-NTA-NanogoldTM See His-tagged proteins directly under EM with gold nanoparticles No silver or gold development required "We've created a simple reagent that labels any His-tagged recombinant protein for imaging, even under EM, in just one step." --James F. Hainfeld, PhD Nanoprobes founder and chief mad scientist. As we develop nanoparticle products for the scientific community, we strive to engineer the most sensitive reagents and nanotechnology for detecting biological molecules. Our unique gold nanoparticle labeling technology uses chemically cross-linked metal clusters and nanoparticles as labels. Unlike conventional immunogold probes, in which colloidal gold particles are electrostatically adsorbed to antibodies and proteins, our gold nanoparticle labels are uncharged molecules which are cross-linked to specific sites on biomolecules. This gives our nanogold probes greater range and versatility than colloidal gold. Our labels can be attached to any molecule with a reactive group -- proteins, peptides, oligonucleotides, small molecules and lipids -- for detection and localization. Other labels can be combined with our gold particle labels; our unique FluoroNanogold probes combine Nanogold® and fluorescein into a single probe for imaging a specimen both by fluorescence and electron microscopy. Our gold nanoparticles, including our Nanogold™ conjugates, and Nanogold™ labeling reagents, are formulated for use with electron microscopy (tem) as well as light microscopy, immunolabeling, x-ray contrast for EM, angiography, mammography and microCT, and for correlative and fluorescence microscopy imaging. New probes can be engineered based on any fragment of a naturally occurring biomolecule, and the label can be positioned away from the binding site so it does not interfere with binding. Our Nanogold® probes have been cited in over 250 publications, and are used in the laboratories of several Nobel Laureates. It's all about creating better tools and finding innovative solutions, so that research and treatments can move ahead. Drop us a line and let us know what you're working on. We'll be glad to help. Nanoprobes, Inc. 95 Horseblock Road, Unit 1Yaphank, NY 11980-2301 USA Tel: 631-205-9490 Fax: 631-205-9493 US toll free: 877-447-6266 © 1990-2017 Nanoprobes, Inc. All rights reserved. Sitemap