"I love Singlera Genomics | The future of cancer testing today from ctmDNA (circulating tumor methylated DNA)"

2022-05-20 13:59:44

Skip to content For Research Use OnlyHomeTechnologyPublicationsAboutContact #fusion-slider-8 .flex-direction-nav a {width:63px;height:63px;line-height:63px;font-size:25px;}Loading...Detect cancer earlier with the power of ctmDNAThe future of cancer testing today, using circulating tumor methylated DNA (ctmDNA).fusion-button.button-1 .fusion-button-text, .fusion-button.button-1 i {color:#ffffff;}.fusion-button.button-1 {border-width:0px;border-color:#ffffff;}.fusion-button.button-1 .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-1:hover .fusion-button-text, .fusion-button.button-1:hover i,.fusion-button.button-1:focus .fusion-button-text, .fusion-button.button-1:focus i,.fusion-button.button-1:active .fusion-button-text, .fusion-button.button-1:active{color:#ffffff;}.fusion-button.button-1:hover, .fusion-button.button-1:focus, .fusion-button.button-1:active{border-width:0px;border-color:#ffffff;}.fusion-button.button-1:hover .fusion-button-icon-divider, .fusion-button.button-1:hover .fusion-button-icon-divider, .fusion-button.button-1:active .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-1{width:auto;}Our Technology.fusion-button.button-2 .fusion-button-text, .fusion-button.button-2 i {color:#ffffff;}.fusion-button.button-2 {border-width:0px;border-color:#ffffff;}.fusion-button.button-2 .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-2:hover .fusion-button-text, .fusion-button.button-2:hover i,.fusion-button.button-2:focus .fusion-button-text, .fusion-button.button-2:focus i,.fusion-button.button-2:active .fusion-button-text, .fusion-button.button-2:active{color:#ffffff;}.fusion-button.button-2:hover, .fusion-button.button-2:focus, .fusion-button.button-2:active{border-width:0px;border-color:#ffffff;}.fusion-button.button-2:hover .fusion-button-icon-divider, .fusion-button.button-2:hover .fusion-button-icon-divider, .fusion-button.button-2:active .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-2{width:auto;}Contact UsHome HomeDale Yuzuki2021-01-26T12:25:27-07:00Applying methylation haplotype analysis to cell-free DNADNA methylation has once been called the '5th DNA base' due to its importance in gene regulation, and has been studied for decades. With the advent of next-generation sequencing (NGS) methylation has been studied on a genome-wide level, an expensive process requiring both generating sequence data and analyzing sequence data many orders of magnitude higher than what a typical clinical laboratory can handle.Targeted methylation approaches have historically not been developed due to technical hurdles. Singlera announces a unique approach, examining methylation haplotypes (adjacent methylation sites on the same contiguous strand of DNA) from cell-free DNA as a method for cancer biomarker detection.By using a highly specific and targeted methylation enrichment method, both the overall sample input requirement is lowered and the overall amount of sequencing necessary for excellent sensitivity is reduced.Empirical Classifier – Derived from over 20,000 methylation haplotypes and 10 years of volunteer samplesHigh Sensitivity and Specificity – Taizhou Longitudinal Study results show greater than 95% sensitivity and over 96% specificityEarly Detection of Cancer – Data suggests detection of cancer four years before earliest conventional diagnosisEfficient biomarker screening technology coupled with fast custom targeted methylation haplotyping and proprietary bioinformatics analysis.ResearchTake a closer look at our leading-edge research in methylation and its role in disease in top research publications.READ LATEST RESEARCHMethodLearn how Singlera’s methylation haplotyping technology can give better cancer biomarker sensitivity.ABOUT OUR APPROACHCollaboration and Co-DevelopmentDo you see promise in our methylation haplotype approach? Do you think it could complement work you are doing in developing in-vitro diagnostics for cancer?CONTACT USResearch Study Results95%Sensitivity of PanSeer 4 years pre-conventional diagnosis96%Specificity of PanSeer across 414 healthy individuals85%Sensitivity of ColonES in Stage I Colorectal cancer91%Specificity of ColonES in healthy individuals 0Taizhou China volunteers0Years volunteers monitored0Number of methylation haplotype markers used in ColonES0Hours from DNA to sequencer-ready library The Co-Founders of Singlera Genomics.modal-1 .modal-header, .modal-1 .modal-footer{border-color:#565656;}×Biography of Yuan (Gary) Gao Ph.D., Chairman and Co-FounderDr. Yuan Gao is an innovator of translational technologies for next generation sequencing, non-invasive prenatal testing (NIPT), DNA methylation sequencing, and digital information storage in DNA. He is also a founder and President of Med Data Quest, Inc., developing clinical natural language processing and machine learning tools to aid precision medicine. He has a Bachelor of Bioscience from Beijing University, a Ph.D. in Computer Science from the Memphis University, completed his post-doctoral training with George Church at Harvard University, and most recently was an Associate Professor at Johns Hopkins University..modal-2 .modal-header, .modal-2 .modal-footer{border-color:#565656;}×Biography of Kun Zhang, Ph.D., Co-founder and Scientific AdvisorDr. Zhang is recognized for multiple achievements including single-cell whole genome sequencing, targeted DNA methylation sequencing, somatic genomic instability in induced pluripotent stem cells, Microwell Displacement Amplification System (MIDAS), and methylation haplotyping technology for non-invasive detection of ctDNA. Dr. Zhang holds a Ph.D. in Human and Molecular Genetics from the University of Texas Houston, completed his post-doctoral training with George Church at Harvard Medical School, and has a B.S. in Biophysics from Fudan University. He currently is a Professor in the Dept of Bioengineering at UCSD..modal-3 .modal-header, .modal-3 .modal-footer{border-color:#565656;}×Johny Zhang, M.B.A., Co-Founder, Chief Executive OfficerJohny Zhang was previously the Vice President/General Manager for Greater China Thermo Fisher Scientific Healthcare, where he was awarded the annual global CEO award for outstanding performance. During his tenure at Gene Company, Ltd, Mr. Zhang introduced numerous molecular diagnostic technologies into China, including Dako IHC, Abbott FISH, Qiagen Nucleic Acid Detection, and Affymatrix Gene Chip. Mr. Zhang co-founded and was COO of www.ebiotrade.com, the first Chinese universal life science website of its kind. Mr. Zhang received his MBA and B.S. in Biochemistry from Fudan University..modal-4 .modal-header, .modal-4 .modal-footer{border-color:#565656;}×Biography of Qiang Liu, M.B.A., Co-Founder, Chief Operating OfficerDr. Liu first demonstrated ultra-low input RNA sequencing and whole-genome bisulfite sequencing in germ cells with Dr. Yi Zhang at Harvard University. She then developed large-scale single-cell RNA sequencing technology for the NIH Single Cell Analysis Program (coordinating laboratories at UCSD, Scripps Inst. and Illumina Inc.) to systematically map single-neuron RNA expression. Dr. Liu received a Ph.D. in Genetics from the Univ of Pennsylvania and did her post-doctoral work with Dr. Kun Zhang at UCSD. She also has a Bachelor’s degree in Clinical Medicine from Peking University and a B.S. in Biophysics from Fudan University..modal-5 .modal-header, .modal-5 .modal-footer{border-color:#565656;}×Biography of Rui Liu, Ph.D., Co-Founder, Chief Technology OfficerDr. Liu first demonstrated ultra-low input RNA sequencing and whole-genome bisulfite sequencing in germ cells with Dr. Yi Zhang at Harvard University. She then developed large-scale single-cell RNA sequencing technology for the NIH Single Cell Analysis Program (coordinating laboratories at UCSD, Scripps Inst. and Illumina Inc.) to systematically map single-neuron RNA expression. Dr. Liu received a Ph.D. in Genetics from the Univ of Pennsylvania and did her post-doctoral work with Dr. Kun Zhang at UCSD. She also has a Bachelor’s degree in Clinical Medicine from Peking University and a B.S. in Biophysics from Fudan University..fusion-button.button-3 .fusion-button-text, .fusion-button.button-3 i {color:#ffffff;}.fusion-button.button-3 {border-width:0px;border-color:#ffffff;}.fusion-button.button-3 .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-3:hover .fusion-button-text, .fusion-button.button-3:hover i,.fusion-button.button-3:focus .fusion-button-text, .fusion-button.button-3:focus i,.fusion-button.button-3:active .fusion-button-text, .fusion-button.button-3:active{color:#ffffff;}.fusion-button.button-3:hover, .fusion-button.button-3:focus, .fusion-button.button-3:active{border-width:0px;border-color:#ffffff;}.fusion-button.button-3:hover .fusion-button-icon-divider, .fusion-button.button-3:hover .fusion-button-icon-divider, .fusion-button.button-3:active .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-3{width:auto;}Yuan Gao Ph.D., Co-Founder and Scientific Advisor.fusion-button.button-4 .fusion-button-text, .fusion-button.button-4 i {color:#ffffff;}.fusion-button.button-4 {border-width:0px;border-color:#ffffff;}.fusion-button.button-4 .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-4:hover .fusion-button-text, .fusion-button.button-4:hover i,.fusion-button.button-4:focus .fusion-button-text, .fusion-button.button-4:focus i,.fusion-button.button-4:active .fusion-button-text, .fusion-button.button-4:active{color:#ffffff;}.fusion-button.button-4:hover, .fusion-button.button-4:focus, .fusion-button.button-4:active{border-width:0px;border-color:#ffffff;}.fusion-button.button-4:hover .fusion-button-icon-divider, .fusion-button.button-4:hover .fusion-button-icon-divider, .fusion-button.button-4:active .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-4{width:auto;}Kun Zhang, Ph.D., Co-founder and Scientific Advisor.fusion-button.button-5 .fusion-button-text, .fusion-button.button-5 i {color:#ffffff;}.fusion-button.button-5 {border-width:0px;border-color:#ffffff;}.fusion-button.button-5 .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-5:hover .fusion-button-text, .fusion-button.button-5:hover i,.fusion-button.button-5:focus .fusion-button-text, .fusion-button.button-5:focus i,.fusion-button.button-5:active .fusion-button-text, .fusion-button.button-5:active{color:#ffffff;}.fusion-button.button-5:hover, .fusion-button.button-5:focus, .fusion-button.button-5:active{border-width:0px;border-color:#ffffff;}.fusion-button.button-5:hover .fusion-button-icon-divider, .fusion-button.button-5:hover .fusion-button-icon-divider, .fusion-button.button-5:active .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-5{width:auto;}Johny Zhang, M.B.A., Co-Founder, Chief Executive Officer.fusion-button.button-6 .fusion-button-text, .fusion-button.button-6 i {color:#ffffff;}.fusion-button.button-6 {border-width:0px;border-color:#ffffff;}.fusion-button.button-6 .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-6:hover .fusion-button-text, .fusion-button.button-6:hover i,.fusion-button.button-6:focus .fusion-button-text, .fusion-button.button-6:focus i,.fusion-button.button-6:active .fusion-button-text, .fusion-button.button-6:active{color:#ffffff;}.fusion-button.button-6:hover, .fusion-button.button-6:focus, .fusion-button.button-6:active{border-width:0px;border-color:#ffffff;}.fusion-button.button-6:hover .fusion-button-icon-divider, .fusion-button.button-6:hover .fusion-button-icon-divider, .fusion-button.button-6:active .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-6{width:auto;}Rui Liu, M.D., Ph.D., Co-Founder, Chief Technology Officer.fusion-button.button-7 .fusion-button-text, .fusion-button.button-7 i {color:#ffffff;}.fusion-button.button-7 {border-width:0px;border-color:#ffffff;}.fusion-button.button-7 .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-7:hover .fusion-button-text, .fusion-button.button-7:hover i,.fusion-button.button-7:focus .fusion-button-text, .fusion-button.button-7:focus i,.fusion-button.button-7:active .fusion-button-text, .fusion-button.button-7:active{color:#ffffff;}.fusion-button.button-7:hover, .fusion-button.button-7:focus, .fusion-button.button-7:active{border-width:0px;border-color:#ffffff;}.fusion-button.button-7:hover .fusion-button-icon-divider, .fusion-button.button-7:hover .fusion-button-icon-divider, .fusion-button.button-7:active .fusion-button-icon-divider{border-color:#ffffff;}.fusion-button.button-7{width:auto;}Qiang Liu, M.B.A., Co-Founder, Chief Operating OfficerDiscover The FutureAt the leading edge of biology and assay technology, Singlera Genomics uses a new biomarker type called ctmDNA (circulating tumor methylated DNA) to peer into the future..fusion-button.button-8 .fusion-button-text, .fusion-button.button-8 i 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