"I love Home - Dystrogen Therapeutics Corporation"

2022-09-07 18:59:39

Skip to contentAboutExpandOverviewExecutive teamChimeric CellsPressPipelinePublicationsContact UsToggle MenuEngineered for PatientsDystrogen TherapeuticsIs a clinical stage chimeric cell therapy company focusing on rare diseases. The company is currently testing Dystrophic Expressing Chimeric (DEC) cell therapy for Duchenne Muscular Dystrophy.Read MoreClinical Studyhow it worksCHIMERIC CELLS Duchenne Muscular DystrophyDystrophin Expressing Chimeric (DEC) cell based therapy developed by Dystrogen Therapeutics aims to target all patients suffering from Duchenne muscular dystrophy, irrespective of existing genetic mutation.Distinct Advantages Over Other DMD ApproachesUniversal therapy for all DMD genetic mutationsProduces the dystrophin protein without genetic manipulation , unlike microdystrophin, the viral vector modified therapy approach targeting DMDDoes not modify genes; no related toxicity or off-target mutations and no viral vector integration issuesDoes not require pretreatment or conditioningDoes not require immunosuppression to support engraftmentRedosing possible without sensitization and no immunosuppression requiredCan be used as a monotherapy or in combination with other therapeuticsChimeric Cell EngineeringChimeric Cell Summary Chimeric cell therapy represents a unique and novel modality with broad applications across multiple therapeutic categories which could revolutionize the treatment paradigm for broad spectrum of genetic disordersEngineered Cell Technology – for Duchenne muscular dystrophy (DMD), a rare, progressive disease without a cure (caused by dystrophin gene mutations) –  the therapy is created by “fusing” myoblasts of normal donor origin (allogenic) with myoblasts of the DMD-affected patient (autologous), to create a new generation of dystrophin expressing chimeric (DEC) cells which contain the phenotype of the normal donor while preserving the surface markers of the DMD recipient. DEC cells express significantly higher levels of CD56 and dystrophin when compared to DMD affected myoblasts, thus more closely resembling healthy myoblasts. Because they are chimeras, DEC cells display the recipients’ immune phenotype, thus does not require imunosupression to support engraftmentActs like a Trojan horse – once injected, DEC cells are recognized by the recipient as “self” and evade the patient’s immune system (are not rejected), and thus engraft, producing the relevant and missing protein from a full-length, healthy gene (delivered by the normal donor)DYSTROGENDystrogen Therapeutics is a clinical-stage life sciences company committed to developing personalized therapies for rare genetic diseases.ResourcesOverviewExecutive TeamChimeric CellsPressPipelinePublicationsFollow usLinkedinTwitter© 2022 Dystrogen Therapeutics Corp - All Rights Reserved #hwp-2230, #hwp-2230 a, #hwp-2230 i, #hwp-2230 .holler-inside, #hwp-2230 .holler-title { color: !important; } #hwp-2230.hwp-template-4 { border-top-color: ; } #hwp-2230, #hwp-2230 .hwp-first-row { background-color: } #hwp-2230 .hwp-email-btn, #hwp-2230 .hwp-progress > span, #hwp-2230 .hwp-email-btn { background-color: } The Treatment of Duchene Muscular Dystrophy Shows Safety and Functional Improvements Dystrogen Therapeutics Investigational Chimeric Cell Therapy DT-DEC01 for the Treatment of Duchene Muscular Dystrophy Shows Safety and Functional ImprovementsRead more Send Holler Box Scroll to topAboutExpand child menuExpandOverviewExecutive teamChimeric CellsPressPipelinePublicationsContact us